Antonio was born in Venice to Francesco Zucchi and became a pupil to his uncle Carlo Zucchi (who devoted his painting career to theatrical painting and design). He became well known as a painter of architecture and engraver and also executed history paintings with Fontebasso and Amigoni. With his brother Adam he travelled the whole of Italy between 1750 and 1760 sketching the ancient monuments and ruins. Afterwards he went to London where he decorated many houses of the nobility - notably the ceilings of Oslerbey Park, Caen Wood and Luton House. He exhibited in London between 1770-1784 and became an associate member of the Royal Academy and married in 1781 Angelica Kauffmann and together they decorated Home House, designed by Robert Adam.